See identical proteins and their annotated locations for NP_001261026. Location: 27 → 597 SLC6sbd_SERT-like_u1 uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily solute binding domain Status: REVIEWED UniProtKB/Swiss-Prot Q7K4Y6, Q9NB97 Related FBpp0086271, FBtr0087125 Conserved Domains (1) summary cd11556 See identical proteins and their annotated locations for NP_523763.2 NT_033778.4 Reference assembly Range 16558567.16565238 complement Download GenBank, FASTA, Sequence Viewer (Graphics) Model RNAs and proteins are also reported here. RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternateĪssemblies. Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as The following sections contain reference sequences that belong to a Orthologous to several human genes including SLC6A2 (solute carrier family 6 member 2). We have examined the effects of methylphenidate (MPD), an inhibitor of DAT, administered alone or with levodopa, on parkinsonism measured with tapping and walking speeds, dyskinesia, subjective effects, and vital signs. The importance of DAT in Parkinson's disease (PD) in which DAT may be reduced by 50 to 70 is unclear. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder hypertension neurocirculatory asthenia nicotine dependence and obesity. The dopamine transporter (DAT) may be the single most important determinant of extracellular dopamine concentrations. The DAT is a target of several drugs, including psychostimulants, such as amphetamine and cocaine, and is also subject to short- and long-term regulation by several drugs and mechanisms. Used to study attention deficit hyperactivity disorder and autism spectrum disorder. The dopamine transporter (DAT) is a transmembrane protein that is responsible for the reuptake of dopamine (DA) from the synaptic cleft and for the termination of dopaminergic transmission. Is expressed in several structures, including central nervous system dopaminergic neurons ectoderm anlage ventral sensory complex primordium and yolk nucleus. Is integral component of plasma membrane. Involved in several processes, including dopamine transport regulation of presynaptic cytosolic calcium ion concentration and response to odorant. Full Name Dopamine transporter provided by FlyBase Primary source FLYBASE:FBgn0034136 Locus tag Dmel_CG8380 See related AllianceGenome:FB:FBgn0034136 Gene type protein coding RefSeq status REVIEWED Organism Drosophila melanogaster Lineage Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora Also known as CG8380 dat Dat dDAT DmDAT Dmel\CG8380 fmn fumin Fumin Summary Enables cocaine binding activity and dopamine:sodium symporter activity.
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